Brendan Rodgers has suffered another selection blow ahead of a crucial month in his tenure as Liverpool manager.
Dejan Lovren, who has started five of the Reds' Premier League games this season, is set to be out for at least two months after suffering suspected ankle ligament damage.
The Croatian international landed awkwardly in extra time of Liverpool's penalty shootout victory over Carlisle United and received oxygen as he was stretchered off the field.
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The defender will have a scan to assess the extent of the damage, but according to the Liverpool Echo, club officials fear he faces a minimum of two months on the sideline.
The 26-year-old could miss vital away fixtures against Everton, Tottenham Hotspur, Chelsea and Manchester City that could define Liverpool's season.
However, the question here is, is it really a big loss for the Merseyside club?
Since his £20 million move from Southampton in the summer of 2014, Lovren has failed to live up to expectations.
His performances last season came in for considerable criticism as Liverpool floundered in the Premier League.
Despite strong displays in the opening three games of this campaign, the Croatian international returned to his form of last season in the 3-0 home defeat to West Ham.
Mamadou Sakho has found his chances limited so far this season but, having signed a new long-term deal last week, looks likely to enjoy a prolonged spell in the first-team.
Before joining Liverpool in 2013, Sakho was producing top quality performances for PSG and has been ever-present in the France national team.
Nobody likes to see injuries, but Lovren's situation may be a blessing in disguise for Liverpool.
If Sakho can develop a partnership with Martin Skrtel in the coming weeks, the Reds may finally have the basis for a strong defence.
Who would you prefer to see partner Martin Skrtel: Dejan Lovren or Mamadou Sakho? Have your say in the comments section below!