The bad news continues to pile up for under-pressure Liverpool boss Brendan Rodgers.
Following the news that Dejan Lovren and Christian Benteke are set for spells on the sideline, Roberto Firmino now faces a lengthy lay-off.
The Brazilian was substituted during the Reds' penalty shootout win over Carlisle United in the Capital One Cup with a back injury.
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And the Liverpool boss believes the £29 million summer signing could have cracked a bone.
As per the Mirror, he said: “Young Firmino landed awkwardly in the game the other night and there is another scan on his back, but he may have cracked a bone in his back.
"We’ll see how he’ll be over the coming weeks, but certainly he’ll be unavailable for tomorrow."
The former Hoffenheim man has hardly set the world alight since moving from the Bundesliga, but the news is still a blow to Liverpool fans hoping to see the South American grow into the Premier League.
The 23-year-old has played a role in all of the Anfield club's league games this season - starting three - but has failed to register a goal or an assist.
With the Merseyside club sitting 13th in the Premier League table, having taken eight points from their opening six games, Rodgers would have ideally wanted a full-strength squad as he looks to save his job.
However, the Northern Irish manager must contend with injuries to three big-name players for the visit of Aston Villa tomorrow.
Top goalscorer, Benteke, will be a huge loss against his former club, but Danny Ings appears to have found form in his absence.
Rodgers will be hoping a victory at Anfield can kick-start his side's season; however, failure to take all three points will only strengthen the calls for Jurgen Klopp or Carlo Ancelotti to replace him.
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