Klose, the 29-year-old top scorer at the 2006 World Cup, misses out after being forced to leave the field with a knee injury on Saturday. Schweinsteiger, 23, misses out because of back problems while 20-year-old Khedira, who plays for German champions Stuttgart, has hurt his right foot.
A statement posted on the www.dfb.de on Sunday read: "Miroslav Klose, Bastian Schweinsteiger and Sami Khedira are withdrawing from the game for the German national team on Wednesday against England in London."
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