Tonight sees the Champions League enter game-week two of the group stages and for the Italian duo in the competition, there is an away trip to Belarus and a home tie against the Europa League winners.
It was a solid opening week for AS Roma and Juventus of the Serie A, with Roma holding last year's champions FC Barcelona to a 1-1 draw in Italy, while Juve started their campaign off in style with a 2-1 win over Manchester City at the Etihad Stadium.
Alessandro Florenzi scored possibly the goal of the tournament for Roma as he leveled things up against Barca from the half-way line and Juve completed a turn-around in England with Mario Mandzukic and Alvaro Morata bagging goals.
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AS Roma Preview
Attentions now turn to game-week two and tonight Roma are in action against BATE Borisov of Belarus.
With Roma already on one point, they are above their opponents, who lost during the opening week against Bayer Leverkusen.
Despite it being away from home, Rudi Garcia's men go into the tie as heavy favourites and are expected to pick up their first win of the Champions League campaign.
After a convincing 5-1 win in the league at the weekend, confidence is high within the Roma camp and they will want to keep that going with a win this evening.
As for Juventus, they have to wait until tomorrow to play their second Champions League game as they host Sevilla.
Juve did very well to come from behind in order to beat Manchester City in the opening game-week, but they face another tough test on Wednesday evening as they host the Europa League champions.
Both teams started their European campaigns with wins, as Juve beat City and Sevilla beat Borussia Monchengladbach.
Despite starting with a win in Europe, Juve's league form has been shocking, and with another defeat over the weekend, pressure is growing on Massimiliano Allegri.
Another win in the Champions League, however, could take some of the pressure off his shoulders.