Ahead of a crucial round of Champions League fixtures that will no doubt hold potential redemption for English clubs after a poor start, there is one team who simply can't afford anything but a victory.
Whilst Chelsea travel to Porto, Manchester United host Wolfsburg and Arsenal get ready to battle Olympiakos; Manchester City train for Borussia Monchengladbach in what is a must-win encounter for the blue half of Manchester.
Before stumbling to a 2-1 home defeat at the hands of Italian champions Juventus, the Blues seemed an unstoppable force - winning all their games and thwarting opposition strike forces.
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Clean sheet after clean sheet, win after win; pundits across the country witnessed the Citizens slaughter every side to cross their path - Ultimately tipping them as Premier League champions come the end of the season.
Seemingly unmatched, undefeated and unstoppable - the icing on the cake being a win to kick-start their Champions League campaign.
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Of course, in typical City fashion, the ghosts of European past haunted the blues and the invincible Citizens were no more thanks to the Old Lady of Italian football.
Disaster for the Blues - and what followed was yet more disaster still. A 2-1 home loss to West Ham ended their Premier League hot streak, in a defeat reminiscent to that of Juventus a few days earlier.
A 4-1 battering of Sunderland in the Capital One Cup followed - but did little to ease the anxiety among City's squad it seems; as Spurs revolted and took advantage.
Being on the receiving end of the same scoreline they won by in the north-east just highlights Manchester City's demons from last season are still very much alive.
The most blatant of them being complacency. For example, for Spurs' equaliser, which, of course, was blatantly offside in the build up; Aleksandar Kolarov did little to close down Kyle Walker and Christian Eriksen.
That's one thing the citizens simply can't afford tonight, complacency. The Blues need to come out the blocks and dominate - with Monchengladbach looking for redemption of their own after a poor start to the Germans' season.
In short, it is a must win game - this one match alone could do so much for City's stumbling form and near enough turn it on its head.