Sevilla welcome Barcelona to the Ramon Sanchez Pizjuan in a re-run of the European Super Cup final from earlier this season.
The nine-goal thriller had just about everything but things have drastically changed for both teams since then.
Sevilla were marooned at the foot of the table for a time, until they managed their first La Liga win at the sixth time of asking.
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Barcelona have had a catalogue of injuries to contend with, Andres Iniesta the latest in a long line to find his way to the treatment table.
As always with this classic fixture, it promises to be an absorbing contest so let's take a look at three things that could shape the outcome...
Emery's poor record
Unai Emery needs a break. In over 20 games against Barcelona, throughout his managerial career he has still never been able to beat the Blaugrana.
After getting Sevilla back to 4-4 after being 4-1 down after an hour in the Supercup, it seemed that Emery would finally break his duck.
Again, it was not to be as Pedro poached the winner with just a few minutes left.
With so many injuries to contend with, Barca are unlikely to be as free-flowing as normal and what better way for the Andalusians to kickstart their season than with a win over the reigning champions.
Barca's defensive woes
Jeremy Mathieu's contribution was woeful against Bayer Leverkusen and gives the clearest indication yet as to a lack of strength in depth at the back for Barca.
Gerard Pique hasn't yet got up to speed after his four-match ban for foul language, and Dani Alves has blown hot and cold.
Only Javier Mascherano has performed at anywhere near his optimum level, and the hosts will surely be keen to take advantage.
The Catalans have only scored one goal in the first half of games this season with most of the action in Barca's half of the pitch.
Sevilla should take a leaf out of Celta Vigo and Bayer Leverkusen's book and attack Barca from the first whistle. It could pay dividends.
No doubt as to who holds the upper hand here.
Sevilla haven't beaten Barca in the league at home since March 2007. Their solitary victory in Andalusia since then came in the 2010 Spanish Super Cup, which Barca won by the odd goal over two legs in any event.
There are reasons why the hosts can be hopeful of upsetting the odds, but if Barca get a foothold early, it could be yet another season before Sevilla beat them in front of their own supporters.