Manchester City striker Sergio Aguero looks set for a spell on the sidelines after suffering a hamstring injury in Argentina's 2-0 World Cup qualifying defeat to Ecuador.
The 27-year-old, fresh from plundering five goals in City's 6-1 Barclays Premier League win over Newcastle last Saturday, was carried off on a stretcher after sustaining the problem to his left leg midway through the first half in Buenos Aires.
Aguero is set for a scan on the injury and is almost certain to miss Argentina's next game with Paraguay next week.
Manchester City confirmed the injury on their website, with a statement that read: "Sergio Aguero lasted just 22 minutes of Argentina's opening World Cup qualifier against Ecuador.
"The City striker, who scored five goals in his last game against Newcastle, pulled up holding his left hamstring while chasing a long ball downfield.
"Former Blue Carlos Tevez replaced Kun who was stretchered off after receiving treatment with the game at 0-0."
Aguero, who has only just returned to fitness after a knee injury earlier in the season, must now be considered doubtful for when City resume their Premier League campaign against Bournemouth on October 17.
Gerardo Martino's men floundered without Aguero as they slipped to a first defeat on home soil since 2009 as goals from Frickson Erazo and Caicedo in the space of 120 seconds gave Ecuador a famous win.
Martino confirmed Aguero will miss the World Cup qualifying clash with Paraguay.
He told the media in Argentina: "He was moving very well and causing a nuisance. We hope he recovers well, but obviously he's a player we will lose."