Just as Manchester City were weighing up their options to make do without Sergio Aguero, who is set to be out for a month according to numerous reports, another spanner was thrown in the works for the Citizens last night.
Unbelievably bad news for City and at such an inconvenient time - just two weeks away from the Manchester derby at Old Trafford, one of their biggest games of the season.
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How long the Spaniard will be out for has yet to be announced, but all the fans can do is pray that he is fit in time for their clash with the Red Devils.
Silva, 29, has been at the forefront of City's glittering start to the campaign - his creativity, agility, awareness and sharp dribbling is something the Citizens really don't want to miss out on, especially now.
Such a long injury list in such a crucial part of the season - how exactly can Manuel Pellegrini work his way round this?
Fortunately, it's no secret that Manchester City raided the transfer market in the summer - signings such as Kevin De Bruyne and Raheem Sterling were partly brought in for moments like this after all.
How will they be utilised though if Silva and Aguero miss the derby?
This would be their best bet...
4-2-3-1: Hart, Sagna, Kompany, Otamendi, Kolarov, Fernandinho, Fernando, De Bruyne, Toure, Sterling, Bony.
Allowing Yaya Toure to play in Silva's usual spot makes up for the loss of creativity - instead, the Ivorian's power and usual control in City's build up play will have more freedom playing in the space in front of United's back-four.
Meanwhile, the Brazilian due of Fernando and Fernandinho provide a solid platform for defensive duties.
Make no mistake, the potential loss of Silva and Aguero is a huge blow for the Citizens and an almighty roar of confidence for Manchester United.
However, if City can utilise the star-studded back-up they have at their disposal correctly, they could still go into this game with the upper-hand.