The four-time Ballon d'Or winner has been out of action since suffering a knee injury during the Catalan club's win over Las Palmas before the international break.
However, Argentina's poor start to their 2018 World Cup qualification campaign - that saw them pick up just one point from matches against Ecuador and Paraguay - means they may rush the 28-year-old back for their next round of fixtures.
BECOME A WRITER
Do you have what it takes? Sign up today and send your 250-word test article: http://gms.to/haveyoursay3
Those games against Brazil and Columbia fall the week before the highly anticipated El Clasico - when Messi is expected to make his Barca return.
The Blaugrana have no power to stop Messi joining up with his national side, as FIFA rules state the player must be released by their club for international fixtures.
Messi could rule himself out of contention but with the next round of international fixtures being so important to Argentina's World Cup hopes, he would more than likely accept the call-up.
Messi's fitness is the primary concern to Barcelona right now. Having lost their two previous away fixtures in La Liga, the Catalan club will be looking to avoid any more slip-ups before his return.
With the Clasico pencilled in as the likely return date, they will be hoping Messi can avoid any further injury setbacks - if he is selected by Gerardo Martino.
Without the mercurial Argentine, Barca have looked a shadow of their former selves. Luis Suarez and Neymar have struggled with the added responsibility placed upon them.
But with a relatively easy run of fixtures before their game with Real Madrid, Luis Enrique will be hopeful his side can take maximum points.
Should Lionel Messi play for Argentina before returning to the Barcelona team? Have your say in the comments section below!