The NFL has extended its deal to host at least two regular-season games a year at Wembley until 2020.
The agreement includes an option to extend it by a further five years until 2025, with all but one of the 12 games that have been played at Wembley selling out.
The Jacksonville Jaguars are due to host at least one of those two games each season. Since 2013, the Jaguars have staged one of their eight 'home' matches in north-west London.
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"This is great news for the team in Jacksonville, which has come to embrace London as our home away from home," said Jaguars owner Shahid Khan.
Khan also owns London-based soccer club Fulham, but he has denied reports that he wants to move the American football team to London.
The NFL has already signed and agreed to a ten-year deal to play two games a year at Tottenham Hotspurs' new stadium from 2018; this would mean at least four matches in the UK from 2018.
Currently, the Jaguars are due to host the Buffalo Bills in London with the second game being played in the England's capital this season. The Kansas City Chiefs are also due to play the Detroit Lions a week after the game, in the third and final match in the UK.
London to host first overseas franchise?
The move could be another step towards the first overseas franchise in American football, with London the destination. The NFL general managers have also expressed an intent to play the sport in other countries and high-profile cities around the globe.
Recently, British chancellor George Osborne entertained the prospect of the move, by inviting a delegation of the NFL to Downing Street, making it a very realistic possibility under UK tax laws if the NFL decides to pursue a London-based team.
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