Crocked Arsenal duo Theo Walcott and Alex Oxlade-Chamberlain will be out of action until after the upcoming international break.
The two England internationals were forced off in the first-half of the Gunners' 3-0 defeat to Sheffield Wednesday on Tuesday night.
Chamberlain pulled up with a hamstring injury, his third since March this year while Walcott strained his calf muscle.
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They join midfielder Aaron Ramsey, who suffered his fourth hamstring injury in 14 months against Bayern Munich, in the treatment room.
The Welsh international is expected to return around the same time, meaning all three players will miss the games with Swansea City, Bayern Munich and Tottenham Hotspur.
As per the Daily Mail, Arsene Wenger said: 'We hope they are light injuries, but they are out until after the international break.'
With Arsenal sitting second in the Premier League - level on points with Manchester City - the loss of Walcott, in particular, is a huge blow.
The winger turned striker has been a revelation this season and Wenger was just beginning to find the right balance between the former Southampton man and Olivier Giroud.
His frightening pace was bringing the best out of Mesut Ozil and he will be sorely missed in the games at Swansea and Bayern, especially, where counter attacking could be key.
Questions have been asked about the training methods being undertaken at Arsenal after the trio of players joined Jack Wilshere, David Ospina, Thomas Rosicky, Danny Welbeck and Mikel Arteta on the sidelines.
An injury crisis at the Emirates seems to be an annual event and it can not be put down to bad luck.
It could end up costing the north London club the title and given their history with injuries, you'd have thought Wenger would try to address the issue.
Are Arsenal's players just injury-prone or is a more deep rooted issue? Have your say in the comments section below