The German has suffered from limited striker options since he took the Anfield hot-seat and has relied on 20-year-old Divock Origi to lead the line in each of his four games in charge.
Benteke made substitute appearances in the Reds' 1-1 draws against Rubin Kazan and Southampton last week after spending over seven weeks out injured. He scored a superb header to give his side the lead against the Saints.
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However, the Belgium international was forced to sit out of Liverpool's 1-0 Capital One Cup fourth round victory against Bournemouth on Wednesday evening with a knee problem.
Klopp has also been without Daniel Sturridge during his time on Merseyside, the Englishman making just three appearances all campaign.
The 26-year-old will miss the clash at Stamford Bridge, but Klopp is hopeful he will at least have Benteke available.
The German told the club's official website, following their victory over Bournemouth: “With Daniel, we have to talk about him when he can train and then he will need, I don’t know, two, three, four, five, six or seven days training.
“Each footballer needs it and it’s not important how good you are unless you have enough strength to play in this really intensive league.
“There is no pressure from me – I can’t put pressure on him or the doctor or the physiotherapist, I have to wait. And when he is back, he has to train.
“I think Christian will be fit on Saturday. He had little problems and with our ‘striker situation’ we can’t take a risk. Divock played again [tonight] and he did well – he worked really hard. But I think Christian will be back.”
Along with Benteke and Sturridge being sidelined, Klopp has also been without Danny Ings, who will miss the rest of the season with an anterior cruciate ligament injury picked up in training.
Origi has been the 48-year-old's main forward but has failed to score for Liverpool yet.
The Belgian has faced heavy criticism from Kopites, who believe he needs to start proving he is worth the £10 million paid for him in 2014.