As great as the Manchester, Milan and Der Klassiker rivalries are, there's only one contender when it comes to club football's biggest match.
El Clasico is by far the greatest spectacle; for many football lovers, it's one of the best moments of a calendar year.
We've seen Ronaldinho, Ronaldo - Cristiano and Brazilian - Lionel Messi, Andres Iniesta and many more superstars produce moments of magic over the years, but what was the best moment?
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Here's a look at five of the most memorable moments from the past decade.
5 - Madrid fans applaud Ronaldinho off the pitch (2009)
Not even Messi has received a standing ovation from the Madrid faithful, so when Ronaldinho walked off the pitch at the Bernabeu to applause from all sections of the stadium, it must have been some performance.
And what a display it was.
The Brazilian scored two dazzling goals in a 3-0 win over the Galacticos; in reality, he could have scored more.
This was the worst Los Blancos side for quite some time despite the huge amounts of money spent on the team - and Ronaldinho exposed every one of their flaws in beautiful fashion.
4 - Mourinho's first win over Guardiola (2011)
Not many managers have got the better of Jose Mourinho, but Pep Guardiola particularly enjoyed unprecedented success against the 'Special One' during his reign as Barcelona manager.
When Madrid faced the Spaniard's side in the 2011 Copa Del Rey final, Mourinho had failed to beat Barcelona in his previous four meetings.
However, a headed goal from Ronaldo inspired his side to a fully deserved 1-0 win, proving that Mourinho could get the better of his well-respected rival. The importance of the win wasn't obvious until the following season, when Real stormed to the league title to end Guardiola's era of dominance.
3 - Barcelona give Real Madrid guard of honour (2008)
The domination of Barcelona and Madrid seems to go in cycles - one team enjoys success for a few years, then it's the others' turn.
Up until 2007, Barcelona had gained the upper hand against their rivals - that era of dominance, however, was well and truly ended.
Madrid, under the stewardship of Bernd Schuster, were in superb form all season, establishing a mighty gap between them and the Catalans. They wrapped up the league title a week before that season's Clasico, prompting Barcelona to endure the humiliation of giving their bitter rivals a guard of honour.
To make matters worse, Madrid went on to thrash them 4-1.
2 - Messi's hat-trick (2007)
The moment Messi well and truly announced himself. Madrid were in better form and feeling confident - very confident - going into the game; they didn't consider the magic of the little Argentine, though.
Barcelona were outplayed for the majority of the game, yet Messi inspired them to a 3-3 draw, scoring a last minute equaliser.
He ran across the box, right to left, before blasting into the corner in a way we have become accustomed to over the past decade. The Argentine has scored many goals against Real, but that hat-trick remains his greatest moment.
1 - Barcelona thrash Real Madrid 5-0 (2010)
It was the most hyped game in recent football history. Barcelona held the league title and possessed arguably the greatest club side that football has ever seen.
However, the Catalans were second in the league at the time to the ruthless Los Blancos, lead by Mourinho in his first season in the capital.
This was Mourinho vs Guardiola as well as Messi vs Ronaldo - no one knew what to expect. What unfolded in the game surpassed even the most optimistic expectations. In what was probably the best all-round performance in club history, Barca thrashed their rivals 5-0.
Messi was unplayable; Iniesta and Xavi were flawless in their touch and passing - Madrid simply didn't have an answer. For the first time in his career, the seemingly untouchable Mourinho was humbled, retiring into his dugout for most of the game and trying to escape any blame for the hammering his side were receiving.
What a hammering it was - surely no Clasico will ever match the drama that unfolded in the Camp Nou that night.
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