Pique, who spent four years with Manchester United - from 2004 to 2008 - feels he has enough experience in England to know that a Spanish team would stand no chance of competing for the title.
The Spaniard made just 23 appearances at Old Traffrd - enough time to experience the brutality and speed of England's top division, it seems.
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He told the Daily Telegraph, "I think that if Barcelona or Real Madrid goes to the Premier League then the first year of playing there, there is no chance of winning it.
"Yes, I think so, because if you go to Stoke, or other types of teams, then it will be really tough."
However, he also believes the same would apply if teams like former employers United or Chelsea came to play in La Liga. It would be difficult for them to cope with the Spanish style of play and struggle to muster a title bid.
Pique won several honours during his time with the Red Devils, namely the 2008 Champions League, before returning to Barcelona, whom he began his youth career with. Since then, he's won a further three Champions League and five La Liga titles.
Despite his modesty, it's hard to picture a Barcelona side boasting a front three of Lionel Messi, Luis Suarez - who has Premier League experience, let's not forget - and Neymar would struggle in the Premier League, let alone challenge for the title.
Moreover, a side containing former Premier League stars Cristiano Ronaldo and Gareth Bale, James Rodriquez and Karim Benzema would suggest that Real would similarly thrive in the Premier League, irrespective of it's renowned physicality.
After all, if even the Premier League's elite struggle contain such strike forces in Europe, who's to say that a wet, cold and windy night in Stoke - as cliche as it sounds - would be able to fare much better? It's unlikely, isn't it.
Football fans: is Pique right? Would Barcelona and Real Madrid stand no chance of winning the Premier League? Let us know your thoughts!