But can Lionel Messi do it on a cold Tuesday night in Stoke? A strange question that has somehow been asked thousands of times ever since the Potters entered the Premier League. Well, as if that fire didn't already have enough fuel, Gerard Pique threw up some controversy when he recently claimed that Barcelona wouldn't win the Premier League, according to Sky Sports.
You don't know what you've started, Gerard.
It's doubtful whether Pique actually meant what he said or was just trying to give a typically modest and unremarkable footballer's answer in an interview. Whether he meant it or not, it's certainly caused quite a debate.
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Barca have easily beaten England's best clubs
Pique's comments seem strange, mainly because of his side's recent record against English clubs. He is either downplaying Barca's chances to potentially relieve some pressure on the Catalan side, or he has a very short memory.
It needed a virtuoso performance from Joe Hart to keep the scores respectable when Barcelona outplayed Manchester City at the Camp Nou last season. City didn't fare much better in the first leg either; Messi missed a last minute penalty to give the English side some hope.
It's not just Manchester City who've looked out of their depth against the Spanish champions; Manchester United were humiliated in both Champions League finals against Barcelona and Arsenal haven't had much more luck against them either. If Barca are destroying England's elite so effortlessly, imagine what they would do if they came up against Bournemouth.
Can Barca handle the physicality
The argument against Barcelona succeeding in the Premier League generally evolves around the physical side of things, like once you come to England all rules are suddenly abandoned. It would obviously be tough for Barca to face the long ball of Watford or the brute force of Stoke. But if the notoriously fragile Wigan Athletic had a good record at the Britannia, it's amazing to think that Barca would struggle there.
When small, compact players like Santi Cazorla and David Silva are dominating the Premier League like they are this season, the current time seems as good as any for Barcelona to pit their wits at the Hawthorns or Villa Park.
When the words came out of Gerard Pique's mouth, his tongue must have been firmly attached to his cheek. If Barcelona were to have a season in the Premier League - the question wouldn't be if they'd win the league - it's how easily would they do so?
How do you think Barcelona would fare if they were in the Premier League? Give YOUR opinion in the comment box below!