England's top flight is the only of Europe's top five leagues that doesn't incorporate a winter break and is widely believed to be a major factor behind the national team's failings.
After failing to surpass the group stages at the most recent World Cup in Brazil, Klopp has highlighted what separates England from the likes of winners Germany.
He said: "Everybody thinks Roy [Hodgson] should lead these boys to the title, they have really good players.
"But they've had no break for one year. All the other teams have. You can be [successful] but it's much harder."
"You have too many games, that's for sure. You have no break, too many tournaments. I think everybody knows that's not the way [to be successful]."
The Premier League is widely renowned for being the most competitive league in world football, which Klopp believes also has a telling impact on English clubs' chances of European glory.
"There are reasons why the big English clubs in the last few years were not that successful," he continued. "You have too many tournaments."
With only one English side - Chelsea in 2011/12 - winning the Champions League in the last seven years, there is a large possibility the Premier League could lose its fourth spot in Europe's elite competition.
With the lucrative television rights deal set to take effect in the upcoming season, the current teams representing England in Europe will have to seriously challenge for the trophy or else the coveted fourth qualifying spot could be in jeopardy.