The absence of the injured Stephen Curry cost the Golden State Warriors dear as they suffered only their second loss of the season on Wednesday night, blown out 114-91 by the Dallas Mavericks.
As Curry, the NBA's leading scorer and reigning MVP, sat with a lower left leg injury, the Mavericks took advantage with JJ Barea scoring 23 points.
Golden State's Klay Thompson struggled in the absence of his fellow Splash Brother, making only four of 15 from the floor for 10 points.
It was a fourth straight win for Dallas, while Golden State can console themselves with a 29-2 record which is still the best in NBA history after 31 games.
But while the Warriors struggled without their star man, the San Antonio Spurs barely noticed the absence of Tim Duncan in a 112-79 rout of the Phoenix Suns.
LaMarcus Aldridge had 21 points and 12 rebounds and Kawhi Leonard added 19 points as the Spurs won a 19th straight home game.
Appearing in Beantown for the final time, Kobe Bryant brought the TD Garden crowd to its feet - even as he beat their team - with a double-double helping the Los Angeles Lakers to a 112-104 win over the Boston Celtics.
Boston fans chanted Bryant's name as he collected 15 points and 11 rebounds for his 173rd career double-double.
Jimmy Butler's tip-in with 1.2 seconds left in overtime lifted the Chicago Bulls to a 102-100 win over the Indiana Pacers.
The Bulls, playing without Derrick Rose, got 29 points from Aaron Brooks and 28 from Butler, with 52 points coming off the bench.
Blake Griffin's continued absence does not appear to be hampering the Los Angeles Clippers, who made it four wins in a row with a 122-117 victory over the Charlotte Hornets.
JJ Redick scored 26 points, Austin Rivers added 22, and Chris Paul collected 19 points and 11 assists as Griffin sat out a third straight game with a left quadriceps injury.
DeMar DeRozan filled up the boxscore with 34 points, six rebounds and five assists as the Toronto Raptors beat the Washington Wizards 94-91.
Nik Vucevic contributed 20 points and nine rebounds as the Orlando Magic beat the Brooklyn Nets 100-93, while June's number one draft pick Karl-Anthony Towns had 25 points, 10 rebounds and two blocks as the Minnesota Timberwolves beat the Utah Jazz 94-80.
CJ McCollum had 27 points and Allen Crabbe 20 as the Portland Trail Blazers beat the Denver Nuggets 110-103 for a third straight win, while Nerlens Noel scored 20 to lead six Philadelphia 76ers in double figures as they beat the Sacramento Kings 110-105 on the road for only their third win of the season.