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England have selected Danny Care at scrum-half and Joe Marler at loosehead prop for Saturday's RBS 6 Nations match against Scotland.
Care has been preferred ahead of long-term rival Ben Youngs in the number nine jersey for the trip to Edinburgh, while Marler has been given the nod ahead of Mako Vunipola.
Back row Jack Clifford, prop Paul Hill and centre Ollie Devoto are set to make their international debuts off the bench at Murrayfield.
Lock Courtney Lawes is included among the replacements after passing a fitness test on his hamstring injury.
"There were some tight calls on selection, but we have picked a match-day squad with a blend of experience and youth," England head coach Eddie Jones said.