This match could throw up a few surprises as the Nuevo Los Carmenes is a ground where Real Madrid have struggled in the past.
With a Madrid derby on the horizon, a fixture that Los Blancos haven't had the lion's share of success in of late, and a four point gap already between themselves and Barcelona, this is a game that Zinedine Zidane's side cannot afford to lose.
Granada themselves have slid down to second bottom on the back of an appalling run of form and if they're not careful, the Segunda Division will beckon quicker than they realise.
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Let's take a look at three things that could affect the outcome of this one...
Since the last fixture of 2015, Granada have shipped at least four goals on four occasions, three against Valencia in another.
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They've also failed to score in four of those eight matches.
Against a rampant Real Madrid, who themselves have scored five or more on three occasions in the same time frame, you have to fear for the hosts.
Jose Ramon Sandoval started off the season so well but the manager hasn't learned from his mistakes and it's threatening to cut Granada adrift.
A gung-ho approach isn't what's required here. Entertainment can go out of the window too. If it brings an appropriate result, the locals are unlikely to be too bothered by how it was achieved.
Lack of discipline
Another thing that has hurt Granada this season is their lack of discipline. Yellow cards aplenty and the odd red.
Forgetting the fact that one more for the likes of David Lomban and Fran Rico will land them a ban, an early transgression here effectively rules them out of the match for they can't risk then getting too tight to Ronaldo et al for fear of the red.
If the defence, in particular, can stay on their feet at all times, then the hosts are in with half a chance.
They only need to recall their performance from a couple of seasons back as to see what's required to frustrate their more illustrious opponents.
Success to bring success?
Isaac Success is an awkward customer at the best of times and Marcelo won't get a moment's peace throughout this 90 minutes.
If the wide man can impose his natural game on the Brazilian, the hosts might garner some success from his deliveries into Youssef El Arabi.
Granada do need to mix things up a bit because if Success gets marked out of the game, there isn't too much else on offer from them in an attacking sense.
At just 20 years of age, Success has the fearlessness of youth and it has been shown time and again before now that if pressure is put on Marcelo he will buckle.