In a week when it was confirmed that Wayne Rooney could be out for up to six weeks through injury, the last thing Manchester United needed was another top player to be struck down.
However, it looks as though the injury curse has struck again for Louis van Gaal after goalkeeper David de Gea limped out of the warm up for the Red Devils' Europa League showdown against Danish outfit FC Midtjylland this evening.
Guardian journalist Jamie Jackson tweeted just moments ago: "De Gea limped out of warm-up..."
As yet there has been no confirmation over whether the Spanish international will be forced to sit out the game this evening, but if he's picked up a serious injury it would be a major setback.
De Gea has kept nine clean sheets this season - the third best record in the league - to help Manchester United concede just 24 goals in 26 games.
Update: Manchester United have now confirmed that Argentine international Sergio Romero has replaced De Gea for the last-32 clash.
A statement has been uploaded to the Manchester United website, which reads: "Manchester United goalkeeper David De Gea suffered an injury in the warm-up for Thursday’s Europa League tie at FC Midtjylland, adding his name to the lengthy list of absentees."
It adds: It remains unclear what type of problem De Gea has sustained and just how serious it might be. The boss will hopefully confirm those details during his post-match interviews and press conference.
As a result of De Gea's injury, Manchester United do not have a goalkeeper on their bench this evening.
Manchester United were knocked out of the Champions League at the group stages, and now look likely to miss out on qualifying for Europe's leading club competition. Six points currently separate them from fourth-placed Manchester City.