Manchester United and Liverpool will meet in the Europa League last 16 next month.
Tottenham, meanwhile, go head-to-head with Europa League favourites Borussia Dortmund.
But it's that huge clash between bitter rivals United and Liverpool that has got everyone talking. The ties will be played on March 10 & 17.
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Meanwhile, Gary Neville's Valencia take on Athletic Bilbao, and FC Basel meet reigning champions Sevilla.
Scroll down to the bottom of this page to see the draw in full.
How they reached the last 16
United advanced to the last-16 thanks to an emphatic 5-1 victory over Danish outfit Midtjylland at Old Trafford on Thursday night.
Louis van Gaal’s side went 1-0 down, leaving them requiring three goals to progress to their next round following their 2-1 defeat in Denmark, but the manager’s blushes were spared thanks to two brilliant performances from Memphis Depay and 18-year-old debutant Marcus Rashford.
Liverpool, meanwhile, sealed their place in the next round thanks to James Milner’s penalty against Augsburg while Tottenham recorded an impressive 3-0 in over Fiorentina at White Hart Lane.
Tottenham are favourites from England's trio
Of the three Premier League teams still in the competition, it’s Spurs who are favourites to win the competition.
Mauricio Pochettino’s side are second favourites with some bookmakers at 7-1.
Liverpool and United are both at 8-1, with Borussia Dortmund the current favourites to lift the trophy at St. Jakob-Park in Basel on May 18.
Europa League last 16 draw in full
Shakhtar Donetsk v Anderlecht
FC Basel v Sevilla
Villarreal v Leverkusen
Athletic Club v Valencia
Liverpool v Manchester United
Sparta Prague v Lazio
Borussia Dortmund v Tottenham
Fenerbahce vs Braga
The Europa League last-16 ties will be played on March 10 & 17.
Which team will win the Europa League? Have your say by leaving a comment below.