Despite disappointing defeats to West Ham and Swansea City respectively on Wednesday night, both sides remain in the hunt for the Premier League title amidst one of the most unpredictable seasons in English history.
Fortunes have considerably changed for Spurs in recent years, however. Four years ago, when Harry Redknapp was at the helm, they lost 5-2 to their rivals at the Emirates Stadium in a match where the hosts proved themselves as north London's dominant side.
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And now, armed with an array of English talent and overall stronger squad, the pendulum has swung and Tottenham look favourites to win at The Lane and close the gap on league-leaders Leicester City.
The difference in all-round quality between Tottenham's current side and the one that fared at the Emirates four years ago is there for all to see.
Starting XI on February 26, 2012: Brad Friedel; Kyle Walker, Ledley King, Younes Kaboul, Benoit Assou-Ekotto; Scott Parker, Niko Kranjcar; Gareth Bale, Luka Modric, Louis Saha; Emmanuel Adebayor.
Only Walker remains from the side that suffered such a capitulation after going 2-0 up, with all others leaving the club since and experiencing mixed fortunes.
Adebayor, for example, scored a penalty during the crushing defeat, but now finds himself at Crystal Palace after falling out of favour at White Hart Lane.
Elsewhere, Gareth Bale and Luka Modric were players of genuine quality for Spurs, but big-money moves to Real Madrid in 2013 and 2012 respectively have seen them both excel.
Even with the aforementioned two in their side, there is little doubt Tottenham's current squad is now stronger and more well-rounded.
Possible starting XI against Arsenal: Hugo Lloris; Kyle Walker, Kevin Wimmer, Toby Alderweireld, Danny Rose; Eric Dier, Dele Alli; Son Heung-min, Christian Eriksen, Erik Lamela; Harry Kane.
And on the bench, Tottenham have the likes of Moussa Dembele and Nacer Chadli to provide further options if needed, with Jan Vertonghen out injured.
Furthermore, Spurs currently boast the strongest defence in the Premier League given their back line has shipped the least goals this season (22) - something unheard of when it comes to the north Londoners.
A disappointing evening on Wednesday aside, Tottenham will enter Saturday's north London derby in the knowing they are far more well-equipped this time around. A shock could be on the cards.