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Ed Slater and Luther Burrell have been called up to the England training squad as replacements for injured duo Courtney Lawes and Marland Yarde.
Northampton lock Courtney Lawes damaged his ankle during Saturday's Aviva Premiership win at Saracens while Harlequins wing Yarde sustained a shoulder injury during his side's loss to Sale.
Their places have been taken by Leicester forward Slater and Northampton centre Burrell in England's 33-man squad which linked up at Pennyhill Park on Sunday evening to prepare for next weekend's crunch RBS 6 Nations showdown with Wales.
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