Liverpool vs Manchester United in a European competition.
It’s never happened before so it was always going to be a lively occasion at Anfield.
The away side had started the match looking fairly comfortable, but in the 20th minute that all changed.
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That’s because Spanish referee Carlos Velasco Carballo pointed to the penalty spot when he adjudged that Nathaniel Clyne had been brought down by Memphis Depay.
Liverpool striker Daniel Sturridge converted the penalty, despite David de Gea getting a hand onto the ball.
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Retired referee Howard Webb believed that the penalty call was correct on BT Sport but that’s not how fans of the Red Devils saw it.
Watch the penalty award here:
As you’d expect, United fans didn’t hold back on Twitter when criticising the ref:
Sturridge’s converted penalty was the only thing separating the two sides during a frantic first-half at Anfield.
But it could have been worse for the away side in the first 45. Just a few minutes away the opener, Sturridge’s screwed shot found its way to Philippe Coutinho on the back post but the Brazilian somehow allowed De Gea to make a save.
And the Spanish stop stopper made a further two fine saves at the half went on to prevent the Reds from doubling their lead.
However, there was nothing he could do when Liverpool capitalised on a Michael Carrick mistake for Adam Lallana to square for Roberto Firmino to prod home with about 15 minutes remaining.
It meant that Liverpool have one foot in the last-eight of the competition following an insipid performance from the away side.
The Reds will be aware that if they score first at Old Trafford in the second-leg next week, the Red Devils will have to score four times to progress.
It means that United's only chance of salvaging something from their disappointing campaign is in the form of the FA Cup. Van Gaal's side face West Ham in the quarter-finals at the Theatre of Dreams on Sunday in their only realistic chance for silverware.
They face a difficult challenge of achieving Champions League football for next season as they trail fourth placed Manchester City with three points, having played a match more.
Of course, it wasn’t the first dubious penalty Liverpool have been awarded recently. On Sunday, Christian Benteke earned a controversial 95th minute penalty when Damien Delaney was adjudged to have clipped his ankle.