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Andy Murray suffered a shock exit at the hands of Federico Delbonis in the third round of the BNP Paribas Open.
World number two Murray, who helped Great Britain to a Davis Cup win over Japan last week, lost a third-set tie-break to bow out, with Delbonis claiming a surprise 6-4 4-6 7-6 (7/3) win.
It prolongs Murray's poor record at Indian Wells and the Scot admits it is not his favourite venue.
"I think it's just the conditions here I have just struggled with throughout my career. I have never really felt that I played my best tennis here," Murray told the official BNP Paribas Open website.
"I have tried and had many different preparations where I've got here early and spent a lot of time on the courts, and sometimes I arrive later, like this time from the Davis Cup.
"Obviously it takes time to get used to new conditions regardless of where it is, but I have just never really found a way to get comfortable here throughout my career. It's a shame."
There were no such problems for third seed Stan Wawrinka, who made safe passage past Andrey Kuznetsov.
The Swiss broke in the 10th game to take the first set 6-4 and then battled back after Kuznetsov was serving for the second set to take it in a tie-break.
Sixth seed Tomas Berdych disposed of Borna Coric in straight sets, winning 6-1 7-6 (7/3), while Australian Open semi-finalist Milos Raonic booked his place in the fourth round when Australian Bernard Tomic called time on the game due to a wrist injury with his opponent 6-2 3-0 to the good.
There were straight-sets wins for Marin Cilic and Gael Monfils, who beat Leonardo Mayer (6-4 6-3) and Albert Ramos-Vinolas (6-1 6-3) respectively.
David Goffin beat Guido Pella 4-6 6-3 6-2 and Richard Gasquet also came from a set down to see off Alexandr Dolgopolov 2-6 6-2 6-1.
In the women's event, British number one Johanna Konta dropped just five games in a 6-4 6-1 beating of Denisa Allertova.
Konta, who could move into the world's top 20 if she goes deep into the tournament, knew she had to be at her best to beat the Czech.
"She came out playing at a high level and I needed to get going," Konta, who was broken in her first service game, said.
"I ran for every single ball, fought the hardest I have ever fought and took some opportunities."
Karolina Piskova gave the injury-troubled Ana Ivanovic the run around, cruising to a 6-2 6-0 win while Roberta Vinci also had a trouble-free clash, seeing off Elina Svitolina 6-1 6-3.
Viktoria Azarenka had to fight hard to get past Shuai Zhang, but the two-time Australian Open winner had enough to win 6-4 6-3.
Switzerland's Timea Bacsinszky was in the wars as she took a tumble in her clash with Eugenie Bouchard, though she picked herself up to claim a 6-2 5-7 6-2 success, but there was shock for her compatriot and seventh-seed Belinda Bencic, who was dumped out 6-4 3-6 6-3 by Magdalena Rybarikova.
Sam Stosur also made it through with a 6-4 2-6 6-4 victory over Christina McHale.