The second Clasico of the season takes place on the first weekend after the international break, on April 2 to be precise, but do Real Madrid stand any realistic chance of beating Barcelona at the Camp Nou?
Zinedine Zidane’s men are currently 10 points behind their fierce domestic rivals, who look almost certain to win La Liga following another superb campaign, and haven’t recorded a league win at Barcelona’s home ground since April 2012.
One of the players who featured in that match four years ago was Cesc Fabregas. The Spanish midfielder entered the fray as an 81st-minute substitute but was powerless to prevent his team from slumping to defeat against Jose Mourinho’s side, who were eventually crowned La Liga champions.
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Fabregas now plies his trade for Chelsea, but he still keeps a close eye on his former employers and all things La Liga.
Earlier this week he took part in an impromptu question-and-answer session on Periscope with his Spain international teammate Gerard Pique and was asked to give his prediction for the upcoming Clasico.
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Fabregas predicts Barcelona will win 2-0
Without hesitating, according to Catalan newspaper Sport, Fabregas answered: "2-0 to Barca.”
Pique, meanwhile, was asked if Barcelona could record a ‘manita’ - five-goal win - over Los Blancos.
Barça famously embarrassed Real Madrid 5-0 back in November 2010 and the club’s fans sense there’s a small chance it could happen again next month.
However, Pique acknowledged that securing all three points is far more important than the scoreline.
"We'll try to win, that will be enough!” the centre-back responded. “It's a difficult topic."
Barcelona hammered Real Madrid in November
Barcelona went close to a manita the last time they faced Real Madrid, back in November.
Lionel Messi was named amongst the substitutes at the Bernabeu, but Rafa Benitez’s side were still hammered 4-0 thanks to a goals from Luis Suarez (2), Neymar and Andres Iniesta.
Zidane confident after win over Sevilla
At this moment in time, there is a gulf in class between Spain’s big two - but Zidane is optimistic his side can secure a shock win at the Camp Nou following Sunday’s emphatic 4-0 victory over Sevilla.
"Before the game I said we had had one of our best week's training and this performance is the fruit of that work. I'm very happy, it's one of the best games since I've been here,” Zidane was quoted as saying by Sky Sports.
"Clasicos are always special. We have to keep improving and it was important to head into it with a victory. We're ready, it'll be a great game."
Do Real Madrid stand a chance of beating Barcelona? Post your score predictions in the comments below!