Many of the world’s best players will be on show, including all three members of Barcelona’s ‘MSN’ (Messi, Suarez and Neymar) and Real Madrid’s ‘BBC’ (Benzema, Bale and Cristiano).
If you’re not yet feeling excited by Saturday night’s showdown, we have something that will whet your appetite: a four-minute video (made by YouTube user CriRo7i) featuring the best goals from recent Clasicos. (Scroll down this page to watch the video).
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The likes of Ronaldinho, Cristiano Ronaldo and, of course, Lionel Messi all feature in the video.
And while they’re all fantastic goals, surely Messi’s solo effort in the Champions League - at the Bernabeu - is the best of the lot.
Video: Most beautiful El Clasico goals
Barcelona firm favourites for title
Victory for Barcelona this weekend will almost certainly see them crowned La Liga champions this season.
Luis Enrique’s side currently have a nine-point lead over second-placed Atletico Madrid - and a 10-point lead over their fierce rivals - with eight matches left to play.
Real Madrid are acutely aware that the title race is virtually over but they will still be determined to record their first win at the Camp Nou since April 2012.
They have the firepower upfront to pose Barcelona’s suspect defence a few problems, but keeping out the ‘MSN’ at the opposite end of the pitch may prove an impossible task.
It was 4-0 when they last met
It finished 4-0 to Barcelona when the two teams last went head-to-head, back in November at the Bernabeu, and Messi only played 33 minutes of that particular Clasico.
Luis Suarez scored twice, while Neymar and Andres Iniesta netted the other two goals as Barcelona humiliated their rivals in their own backyard.
With Messi - who has scored more goals in the Clasico than any other player in the fixture’s history - fully fit and firing, there’s a chance Real Madrid could suffer another embarrassing defeat this weekend.
Another 5-0 on the cards?
Gerard Pique was recently asked whether Barcelona were capable of recording another ‘manita’ - a five-goal win - over Los Blancos, like they did in November 2010, and the centre-back gave a diplomatic answer.
"We'll try to win, that will be enough!” Pique responded. “It's a difficult topic."
An emphatic Barcelona victory, however, is not beyond the realms of possibility.
Real Madrid have struggled for consistency under Zinedine Zidane, who replaced Rafael Benitez in January, although they do come into this weekend’s fixture off the back of five straight wins in all competitions.
Will Barcelona hammer Real Madrid? Post your score predictions in the comments below!