The Argentine opened the scoring in the 33rd minute with a deflected effort from just outside the box before doubling the visitors' lead early in the second half, finishing off a counter attack with a sublime finish.
His third came from the spot after Chelsea 'keeper Thibaut Courtois saw red for bringing down Fernandinho in the box, Aguero calmly stepping up to slot past Asmir Begovic.
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The 27-year-old's efforts brought his season's tally in the league to 21 goals - 13 of which coming in his last 12 Premier League games - and saw him close the gap on top goalscorers Harry Kane and Jamie Vardy.
Aguero's superb performance was a timely reminder of why he remains the best striker in the Premier League, despite trailing in the goalscoring charts. One only needs to look at his goals-per-game ratio to see how superior his record is to his peers.
Kane and Vardy are currently netting one goal in every 0.66 and 0.65 games respectively in the league, whilst Aguero is scoring at an incredible rate of one goal in every 0.84 games (21 in 25 appearances).
His speed, agility and ability to score any type of goal make him the perfect goalscorer and when on top form, he's unstoppable.
Furthermore, Aguero consistently performs on the big occasions, with no greater example than his title-winning goal in the 94th minute against Queens Park Rangers in 2012.
He's without doubt the most reliable and consistent goalscorer the Premier League has seen over the past five seasons, with Aguero's importance to City undoubted given their well-documented struggles in his absence.
The Argentina international's record in England further serves to prove his quality - he will become just the 25th player to score 100 Premier League goals the next time he finds the net and in the third fewest games (145) behind Thierry Henry (140) and Alan Shearer (134).
Aguero has maintained his world-class status at the Etihad even despite his many injuries and, quite simply, he's unrivalled when it comes to all-round quality and the best striker in the Premier League.