Wolves manager Mick McCarthy hopes Chris Iwelumo's red card will be rescinded after Preston defender Sean St Ledger pleaded the striker's case to referee Martin Atkinson.
Iwelumo was sent off for clashing with St Ledger minutes after completing the hat-trick which moved Wolves three points clear at the top of the Championship.
"St Ledger has been in to see the referee to say that nothing happened and you can't get a better witness than that," McCarthy said. "All credit to him, he's been up against a player who's given him a real battle and has scored a hat-trick and yet he's still gone in to see the referee."
"It was a strange afternoon for Chris," he added. "He played exceptionally well, scored a hat-trick and got the match ball, and then got sent off!
"It was nothing, not a clash of heads, and bearing in mind the witness is the other player involved I would hope the sensible thing will be done and it will get rescinded."
Wanderers also had goalkeeper Wayne Hennessey dismissed for bringing down Neil Mellor in the closing stages of the visitors' 3-1 win.
McCarthy accepted Hennessey's red card, adding: "I've spoken to the assessor and the letter of the law is that if you deny someone a goalscoring opportunity you are sent off."
Preston manager Alan Irvine could not hide his disappointment after watching his side surrender their unbeaten league run. He said: "I'm obviously disappointed with the result, with the way we played and with the goals we conceded.
"We didn't perform at the level we have been performing. Obviously Wolves are a very good side. Goals change games, we know that and if we had got an early goal it could have been a very different story.
"But you have to look beyond those things to the things you can control like how you play, how you perform."
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