Isco has been dealt another blow by Zinedine Zidane after the Real Madrid manager has decided to sell up, providing they receive a reasonable offer.
Reports in Spain claim that players will have to leave the Bernabeu before Madrid can make any big signings this summer and Isco is thought to be in the most danger of not making the cut.
The Spanish midfielder struggled to make much of an impact after Zidane replaced Rafael Benitez in January, therefore it doesn't come as much of a surprise to find out Isco is now considered surplus to requirements, according to AS.
James Rodriguez has been heavily linked with a big-money move away throughout the summer but Madrid could have more luck finding a new club for Isco.
Arsenal are one team who are thought to have held some interest in the past, however, Arsene Wenger has made signing a striker the top priority over any other positions.
Wenger may also feel confident he already has enough attacking midfielders at his disposal to get through the season, making a move for Isco at this time appear particularly unlikely.
It was only in June that Zidane claimed the 24-year-old would not be going anywhere this summer following speculation he might have been used as part of the deal to bring Alvaro Morata back to the Bernabeu.
But with the new season rapidly approaching, it looks like the Madrid boss has had a change of heart and might be willing to let Isco depart if it allows him to strengthen the squad.
The same article also suggests Madrid officials value the ex-Malaga man somewhere in between the £100 million Manchester United are expected to pay for Paul Pogba and the £37 million Pep Guardiola spent to bring Leroy Sane to the Etihad - which in truth, doesn't exactly narrow down how much we should expect Isco to go for.
However, what we do know is Marco Asensio will be staying in the Spanish capital after an impressive loan spell at Espanyol last year and is expected to nudge Isco even further down the pecking order.
Isco - a former Golden Boy winner in 2012 - looked like he would become a key man at the Bernabeu after his first campaign but year-by-year, his role and influence in the side has waned and now might just be the perfect time for a fresh start to get his career back on track.