The Gunners were blown away at the Emirates Stadium by a number of fantastic goals, with Philippe Coutinho's free-kick the pick of the bunch.
So dominant were Liverpool that they were 4-1 up by the 63rd minute, though goals from Alex Oxlade-Chamberlain and Calum Chambers set up a nervy finish.
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Typically, Wenger has since bore the brunt of criticism from fans and media alike, with his side's defeat a timely reminder of how his days at the Emirates Stadium could well be numbered.
But for one Manchester United legend, the Frenchman should stay on as Arsenal manager and deserves the utmost credit for the job he's done.
That man is Gary Neville - and he's a big fan of Wenger's, it seems.
Speaking on his Gary Neville Podcast, per Sky Sports, he said: "I am sure when Arsene Wenger is not here, there will be a massive amount of admiration for what he has achieved at this football club.
"I would advocate him staying on because it feels like we have new managers every 10 minutes and he is a stalwart.
"You look at what he has achieved - he is the most successful manager in their history.
"Unfortunately, the shame of modern football as it is, we don't appreciate stability and continuity as much as we should. When you sign five or six players and sack your manager, it's almost like fans are invigorated again."
Despite his admiration for Wenger, Neville understands the frustration amongst supporters.
"There is a feeling among some fans that Arsenal are lacking inspiration," he added, "and it shouldn't be like that on the first day of the season.
"Some Arsenal fans are feeling a bit tired."
Such discontent is understandable, of course, following a summer where Wenger has spent a meagre £34 million on new arrivals.
And the Frenchman's tight approach in the transfer market came back to bite him on Sunday after fielding the inexperienced duo of Chambers and Rob Holding at centre-back.
On Arsenal's defeat, Neville said: "It didn't feel like an opening weekend game. There was a point in the second half when it felt like a cup match, end to end.
"The first half Arsenal were the better team, Liverpool just didn't play. But the big moment in the game was the Philippe Coutinho free-kick just before half-time.
"It was a killer blow for an Arsenal team lacking experience and leadership."