Fantasy football lovers everywhere have just had their ultimate nightmare come true.
Sergio Aguero will sit out the next three games through suspension after he was found guilty of violent conduct, so that leaves a gaping hole in DraftKings' fantasy line-ups.
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Never fear, though, as there are still plenty of players to choose from who are set to make a big impact on the Premier League this weekend. The Manchester Derby is all fans are talking about, but there are quite a few games elsewhere that could prove decisive later on in the season.
Tottenham and Arsenal have both had stuttering starts, leaving Manchester to rule the roost. Although that's not entirely true, as Antonio Conte's Chelsea have picked up maximum points from their first three games and are looking more like the Blues of old.
With Leicester also having mixed results, it would seem the natural order of English football has been restored, if it weren't for Everton propping up the top four. Big things are expected of Ronald Koeman's men this season, so it remains to be seen whether they can live up to the hype.
And speaking of fulfilling expectations, three players in particular have the opportunity to do just that this weekend - and that makes them the perfect choices for the latest round of DraftKings.
United's wonder kid simply refuses to be chucked out of the spotlight by Zlatan Ibrahimovic and is determined to show he's one for the present, not just for the future.
Just as the Old Trafford faithful were questioning how much of a role the 18-year-old was going to play under Jose Mourinho, up popped the striker to break Hull's hearts in the 92nd minute, securing the Red Devils a 1-0 win. That earned Rashford 10 fantasy points, just as it did seven times last season, despite only having made his debut in February.
For such a young player, the Manchester-born lad has impressive confidence, which means he's never too shy to take on a shot. The striker averages three shots per game so far this season, with each attempt earning him one point, with double that if they're on target.
Click here to select Marcus Rashford.
The pressure was on Arsene Wenger to sign a centre-back. Now he's got one, there's even more pressure on Shkodran Mustafi to perform. In the absence of his compatriot Per Mertesacker, the Germany international will be stepping out for the first time in an Arsenal jersey against Southampton.
The 24-year-old is strong in the air and is also an impeccable tackler, which are worth one point so picking him will at least earn your DraftKings line-up some precious points.
Mustafi is exactly the kind of gritty defender the Gunners needed and if he really is the answer to Wenger's problems at the back, then perhaps they can keep only their second keep clean sheet of the season against the Saints - and earn the new boy 3 points as a result.
Click here to select Shkodran Mustafi.
Everton have something to prove this season, but Ross Barkley has even more of an incentive than any of his teammates after he was dropped by Sam Allardyce for the new England manager's first squad.
Exactly where the midfielder picks up his points this weekend depends largely on where he plays; if he operates on the left, expect lots of 0.75 fantasy points for crosses, or even 6 points if they turn out to be an assist.
If Koeman places him in the centre, interceptions are worth 0.5 points, but either way, against shaky Sunderland, Barkley is set to boss the show.
Click here to select Ross Barkley.