Manchester United and Jose Mourinho head into unfamiliar territory this week with their first tie in group stages of the Europa League.
They kick off the competition with an away trip to face Dutch side Feyenoord on Thursday night.
Fans were wondering how seriously Mourinho would take Europe's second-rate competition and know a bit more about his ambitions after his squad for the Feyenoord clash was announced.
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The Portuguese boss did hint he would rotate the team after Saturday's derby defeat to Manchester City and he wasn't kidding, with some big names missing out on selection.
Most surprisingly, club captain Wayne Rooney has not been included while Mourinho has also opted to leave Antonio Valencia, Luke Shaw, Jesse Lingard and Henrik Mkhitaryan at home.
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Lingard and Mkhitaryan were shock starters in the 2-1 loss to Pep Guardiola's side last weekend but were both hooked off at half-time after a disappointing 45 minutes.
Mkhitaryan, who joined from Borussia Dortmund in the summer, is believed to have aggravated a thigh injury picked up on international duty and could miss United's next three matches.
Shaw had to pull out of the England squad that beat Slovakia last week and Mourinho is happy to limit the left-back's involvement as he continues his gradual comeback for the double leg-break he suffered 12 months ago.
But it is Rooney's absence which has drawn the most reaction on social media.
The captain struggled to make much of an impact against Man City and has been shipped out on the wing during the last two matches when Mourinho has been seeking a goal.
Although he set up Rashford's winner at Hull, Rooney no longer has the invincible status he once had at Old Trafford and whether he has been simply rested or actually dropped, Red Devils' fans are pleased he has not made the cut.
Here are some of the best tweets:
In regards to who will be flying to Holland, Zlatan Ibrahimovic, Paul Pogba and Eric Bailly have all been included alongside Marcus Rashford.
The Man United boss has already confirmed that Rashford will start the game after impressing in his cameos off the bench so far this campaign.
The full squad for Thursday's clash against Feyenoord: De Gea, Romero, Johnstone; Darmian, Bailly, Blind, Fosu-Mensah, Rojo, Smalling; Carrick, Fellaini, Herrera, Mata, Memphis, Pogba, Schneiderlin, Young; Ibrahimovic, Martial, Rashford