In a season where we have seen several big names drop due to injury already, the Houston Texans may have just been dealt the worst injury blow of them all.
The Dallas Cowboys are missing Tony Romo, Chicago Bears have lost Jeremy Langford and Adrian Peterson has seen his season end already.
For Houston, their big injury comes on the defense as three time defensive player of the year J.J. Watt has once again hurt his back.
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Watt was largely ineffective in the Texans' 27-0 shutout defeat to the New England Patriots in week three but he could now be set to spend the rest of 2016 on the sidelines.
A source close to the team confirmed that Watt is now expected for a long lay-off and that the Texans are expected to place him on injured reserve on Wednesday.
The hopes at this point are that Watt will be able to return for a late season play-off run but that will depend upon the actual severity of the injury.
Watt missed the entire pre-season through injury as he recovered from off-season surgery to repair a herniated disk.
Houston have reportedly already made a move to maintain their level of depth on the defensive line by trying to re-sign defensive end Antonio Smith.
Watt now looks almost certain to have to wait until next year to try and mount a challenge for his fourth defensive player of the season award.
The period ahead without Watt has just become a lot more difficult for the Texans who host the Tennessee Titans on Sunday.
With the likes of C.J. Anderson, Frank Gore and DeMarco Murray all set to play the Texans in the next few weeks, Watt's absence will surely be felt.