The Red Devils enter the clash on the back of a recent run of poor form, while their hosts have been nothing short of fantastic since their 4-1 win over Leicester City last month.
What makes the affair such a mouth-watering one is the fact both sides are expected to challenge for the Premier League title this season, especially so Jurgen Klopp's men, who currently sit fourth and two points off top spot.
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A thrilling encounter is to be expected, then, but the truth of the matter is that Liverpool and United's rivalry isn't like it once was.
No longer is it a fight to the death like during the Sir Alex Ferguson and Rafa Benitez era, when there was a distinct hatred between the two sides.
Ahead of Monday's game, former United ace Nani has given an insight into what the dressing room was like before playing Liverpool, also explaining how Ferguson used to motivate his players.
He told Omnisport, per Manchester Evening News: "When you play that kind of game it gives you great motivation. It pushes you in the league, it makes you stronger.
"Ferguson used to say that this is not just a game - it's a challenge. Everyone must win their battle against their opponent. We're not just playing, we're going out there to win.
"Win every ball, tackle, race, everything. Football comes last. We didn't always play beautiful but played hard."
It's little wonder United were so successful under Ferguson, who Nani claims is the "100 per cent" the best ever manager in English football.
"100 per cent he is the greatest manager in Premier League," the Portuguese added.
"The way he works, the way he was with us. Not just because he wins all the trophies, the way he prepares, approaches each day and each game.
"He had the motivation and was strong when he needed to be. He could do the human side.
"I'm very happy to be part of his story, and happy he's part of mine. I will remember him always."
Victory for United on Monday would potentially see them leapfrog Liverpool in the table, depending on the margin they win by.
As for their hosts, they could go top with a win if Manchester City, Tottenham and Arsenal all lose their respective games.