With both sides vying for a Champions League spot this season - and perhaps even the Premier League title - a titanic clash is widely expected on Merseyside.
Jurgen Klopp's men are favourites heading into the match having won four of their last five league games, whereas United have struggled for consisency and most recently slumped to a 1-1 draw with Stoke City at Old Trafford.
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Jose Mourinho will only hope his players return from the international break reinvigorated and ready to cause an upset.
Much has been made of team news and form in the build-up, but what's perhaps most interesting is a joint statement released by the two clubs today.
Posted on Liverpool's official website, it pleaded to those in attendance of Monday's fixture to refrain from any "offensive or discriminatory behaviour" and instead keep the peace.
The statement said: "Both clubs, their supporters and football fans around the world are looking forward to this historic and passionate match between two of the sport's biggest and oldest rivals.
"There is great rivalry between our fans and we ask all supporters to be respectful and help eradicate all forms of offensive and discriminatory behaviour from the game.
"If any supporters are found to be engaged in any form of offensive or discriminatory behaviour by stewards or via CCTV then they will be immediately removed from the stadium, risk arrest, prosecution and be reported in accordance with the club's ground regulations.
"This is an unrivalled fixture in the Premier League calendar and we thank all fans for their continued support in this important area of the game."
An estimated 700 million people from 200 countries are expected to tune into Liverpool's game with United, giving reason for both sides to prevent any violence from being televised.
A spokesperson from Kick It Out, which campaigns against racism, lauded the two English giants for the message they sent to their fans.
"Both Liverpool and Manchester United should be commended for this proactive approach ahead of this important fixture," they said.
"We always encourage supporters to report any form of discrimination they may see or hear. Our reporting app, which is available to download from the App Store and Google Play, allows users the option to attach photos and videos."