It's almost impossible to call which way the Anfield encounter is going to go, with a United victory edging them closer to the Jurgen Klopp's men in the Premier League table.
Unsurprisingly, after an impressive start to the season, the Reds go into the game as slight favourites, but former United right-back turned pundit insists the hosts won't be invincible.
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Given some of the Red Devils' recent lacklustre displays, it's hard to see how they are going to break their rivals down, but as Neville points out, there is one huge weakness they can exploit.
“The big weakness for Liverpool on Monday is set pieces,” he told Sky Sports.
“If United put the ball in the box around the goalkeeper and the back four there's going to be problems.
“That's the way Liverpool are at the moment. Even against Arsenal in the first game of the season it was 4-1 and Arsenal made it 4-2 and you could see Jürgen Klopp on the sidelines thinking 'do I quite trust these?'”
Although the German's side perhaps don't quite look the finished article, this season, they have plenty of experience of coming out on top in the big games.
Not only did they start the campaign with victory at Arsenal, they also held onto a 2-1 lead against Chelsea at Stamford Bridge.
“To come through it (against Chelsea) when it was 2-1 was a big moment to give them the confidence that they can actually hold on to a lead," Neville added.
"They did it at Arsenal as well, but they still look a little bit weak defensively."
United will be hoping they can take advantage of the Merseysiders' frailties at the back, though they have their own concerns in that department, having failed to keep a clean sheet in any of their last four league games.
It's certainly going to be an unpredictable encounter, and if Jose Mourinho's side walk away with anything less than three points, they could be in real danger of falling behind.
Can United beat Liverpool at Anfield? Have your say in the comments.