A win for Jurgen Klopp's side will put them joint top with Manchester City and Arsenal on nine points, and on current form, it looks like that result is perfectly plausible.
The Reds have lost just one league game all season and have won their last five games in all competitions. United, meanwhile, could muster no more than a 1-1 draw with Stoke at Old Trafford in their most recent Premier League outing.
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Klopp certainly looks more relaxed about the game than Jose Mourinho, who knows he has a point to prove at Anfield.
There's nothing Liverpool fans like less than losing to the Red Devils, and with their Portuguese nemesis in charge, tensions are going to be at an all-time high.
However, according to one stat, it may not be quite as easy for the home side as many are predicting.
Yes, Liverpool have the benefit of a rejuvenated, redeveloped Anfield Main Stand, while their front three are playing much more cohesively than United's ever-changing attack.
Opta have it, though, that the Reds actually have quite an unwanted record against their old rivals from across the north-west.
Liverpool have lost more league games against Manchester United than against any other team.
Of course, there are lots of reasons why that could be the case, such as the fact that the two sides have nearly always been in the same division.
Yet, in the words of Sir Alex Ferguson, United love any given opportunity to "knock Liverpool right off their f***ing perch", and tonight would be the perfect chance to do just that.
Klopp's men need a result to prove themselves as genuine title contenders, but it would also represent something bigger than that.
With Mourinho's misfiring stars languishing in seventh place, defeat to Liverpool would all but confirm a shift in power this season and maybe even beyond.
Who's winning this one - Liverpool or Manchester United? Have your say in the comments.