The Frenchman bagged a brace against Fenerbahce in midweek, but at Stamford Bridge, it was a very different story as the 23-year-old struggled to make his mark.
With a price tag of £89million, it's about time the former Juventus superstar started to have an impact on the big games, aside from inspiring derisory chants from the Chelsea fans about the money spent on him.
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Pogba was far from United's only flop on display, but as the world's most expensive player, he's always going to be under more scrutiny than most.
Yet, it's one thing for the midfielder to be ridiculed by opposition supporters, but quite another for Chelsea's official media to start milking their emphatic win at his expense.
The Blues' official Twitter account could hardly contain themselves throughout the thrashing; that's fair enough, as this was a hugely momentous moment in the season for Antonio Conte and his players.
When Pogba got himself booked for a tussle with Nemanja Matic, however, it was just all too much, leading to this lovely little dig:
Professionalism embodied. It's nice and subtle, but it gets the point across perfectly.
Pogba disappoints again
To make matters worse, Chelsea's own summer signing N'Golo Kante was superb, slipping past United's midfield, wriggling through their defence, and cooly slotting past David De Gea for the fourth goal.
Jose Mourinho will no doubt be the most heavily affected by the defeat, as he would have so dearly loved to get one over on the club who sacked him last December.
A number of United players should be looking at themselves, though, Pogba included. Chris Smalling, in particular, endured a torrid time at the hands of Chelsea's front line, while Zlatan Ibrahimovic is now in the midst of his longest goal drought for six years.
That won't take away from the pressure on Pogba, as he really needs to prove he's a game-changer if he's ever going to live up to his transfer fee. Otherwise, he can expect plenty more of this kind of thing on social media.