Both sides are vying for Premier League glory this season, with Arsene Wenger's men joint top of the table on 23 points and just three ahead of their rivals.
Home advantage - and form - is with Arsenal, who are unbeaten in 15 games in all competitions, while Tottenham are winless in their last six.
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But if any lesson is to be learnt from previous encounters between the two, it's that anything is possible and nothing is guaranteed.
Arsenal and Tottenham's strongest starting line-ups are just about as even as they've ever been, with pundits and fans alike creating combined XI's in the build-up to Sunday's affair.
Piers Morgan has now become the latest to propose his strongest 11, using seven Arsenal players and four from Tottenham (see below).
MORGAN'S COMBINED XI
And here it is: Petr Cech; Hector Bellerin, Toby Alderweireld, Laurent Koscielny, Danny Rose; Santi Cazorla, Mousa Dembele; Theo Walcott, Mesut Ozil, Alexis Sanchez; Harry Kane.
Not quite as one-sided as you might have imagined.
Morgan still makes a few questionable selections, with Rose over Nacho Monreal and Dembele over the likes of Aaron Ramsey, Granit Xhaka and Francis Coquelin particularly controversial.
Even choosing Cech over Hugo Lloris is a bold move, with Tottenham's goalkeeper a sensational shot-stopper and one of the world's best.
As for Alderweireld and Kane, they both fully deserve their places in Morgan's XI.
Alderweireld has been nothing short of fantastic since joining Tottenham in 2015, whereas Kane has enjoyed two phenomenal seasons in the Premier League and is - on his day - a superior striker to Olivier Giroud.
Morgan's strongest 11 was always going to be dominated by Arsenal players, but those who he has picked are there for good reason.
Bellerin and Koscielny are amongst the best in their respective positions in the Premier League; Cazorla is technically superb in central midfield; while Ozil, Sanchez and Walcott have been simply outstanding this season.
Sunday should prove to be a thrilling affair.