It's not the news the Buffalo Bills wanted if they had any hopes of keeping their playoff hopes alive this season.
Entering the game, running back LeSean McCoy had rushed for 683 yards and six touchdowns on 113 attempts and was one of the main reasons why the Bills are looking like they could reach the postseason for the first time since 1999.
Yet those hopes could now be diminished, as Shady has picked up an injury.
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The 28-year-old picked up a thumb injury during his team's week 11 game at Cincinnati against the Bengals. He had five carries for 33 yards with a touchdown before leaving the field.
He has since been ruled out of the contest and will not return which must be disheartening for Bills fans, but according to reports, things aren't as bad as they first seem.
NFL Insider Ian Rapoport tweeted: "Tho LeSean McCoy was ruled out, #Bills sources don't seem concerned with what is described as a dislocated thumb (that he couldn't pop back)"
It sounds as though McCoy won't be missing any time at all, and he could have actually played on against the Bengals if he was able to pop his thumb back in. That should bring a sigh of relief to every Buffalo fan.
The Bills will be hopeful Shady is able to play next week when they take on the Jacksonville Jaguars to help keep their playoff dreams alive.