Injuries have not been kind to Real Madrid this season.
Toni Kroos, Fabio Coentrao, Danilo, and Pepe could all miss this weekend's El Clasico as Los Blancos look to extend their lead over Barcelona to nine points.
It's fair to say Zinedine Zidane has even bigger concerns, though, over the fitness of Gareth Bale.
Even with Cristiano Ronaldo firing on all cylinders, the attacker is a huge loss for the European champions, and at a time when Barca look ripe for the taking in the derby after a poor performance against Hercules.
The 27-year-old was taken off in last week's Champions League game against Sporting Lisbon after suffering a kick on the ankle, but at the time it seemed that Zidane was just taking the necessary precautions.
Bale did not appear to even be hurt, but perhaps he's made of sterner stuff than we all realised.
Real medics later ruled him out for two to three months, but it seems even that was wishful thinking.
Guillem Balague writes in AS that the injury is actually much more serious than was first feared, and the Welshman could be sidelined for as long as four months - an equivalent of 25 games.
According to Balague, the star has suffered "a traumatic dislocation of the peroneal tendons in his right ankle". You don't have to be a doctor to work out that is very bad news indeed.
It effectively rules Bale out for the majority of the season, and he may not play again in the Champions League unless Madrid reach the final.
Unsurprisingly, Wales fans aren't too happy about it either, with their star man also set to miss their World Cup qualifier against Ireland in March.
Bale's absence is ultimately going to be a huge blow to both club and country, and however strong Real's squad is, he would have been one of the last people Zizou would have wanted in the treatment room.
Will Real Madrid win La Liga without Bale? Have your say in the comments.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: http://gms.to/writeforgms