Manucho pounced deep into stoppage-time to clinch a dramatic 1-0 victory for Hull at Craven Cottage.
The Tigers were under siege for most of the second half yet Manucho combined with fellow substitute Richard Garcia, who had been on the pitch for two minutes, to secure an unlikely three points.
Bobby Zamora, Andrew Johnson, Clint Dempsey and Simon Davies should have put the Cottagers out of sight 20 minutes into the second half but failed to convert.
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