The writing has been on the wall for some time. During the January transfer window Wayne Rooney was believed to be heading to China to enjoy the riches the game has to offer in the far east while winding his long career dawn.
The Red Devils skipper has looked decidedly off colour this season and when he has played he's struggled for goals, despite making himself the club's all-time top scorer in the process.
But having returned from an ankle injury, he was in the squad for United's Europa League clash with Belgian side Anderlecht, though his failure to make it off the bench didn't go unnoticed.
With United desperately needing a goal and Zlatan Ibrahimovic going off injured, many thought the England international was a sure thing to come on.
Only it didn't pan out that way and youngster Marcus Rashford eventually saved the day with a goal in extra time to see United through to the semi-finals.
As well as China, Rooney was linked with a return to boyhood club Everton, though Jose Mourinho has previously stated that he hoped to keep him beyond the end of the season.
But following the game, former United skipper Roy Keane said that he believes the snub signals the end of the line for Rooney at the club.
"In terms of the bigger picture, that is the end of Wayne at United," he told ITV Sport (via the Daily Mirror).
"He will contribute from now until the end of the season but that is the final nail in the coffin for him.
"He must be fuming, he'll be like a mad man. If he isn't then he has lost the eye of the tiger."
United could now face one of Lyon, Ajax or Celta Vigo en route to the final, with Lyon looking to represent the biggest challenge to their hopes of winning the competition.
The French side managed to squeeze their way past Turkish giants Besiktas on penalties.
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