Last season's losing play-off finalists Millwall claimed an emphatic 4-0 Carling Cup first-round victory over League Two Bournemouth thanks to a hat-trick by Neil Harris following Gary Alexander's opener.
MK Dons were on the wrong end of a 4-1 home defeat by Swindon.
Jon-Paul McGovern put the visitors ahead with a 30-yard shot in the 41st minute before Jermaine Easter levelled with a penalty eight minutes after half time.
Billy Paynter restored the lead with the first of his two goals before David McCracken's headed own goal sealed a miserable night for the Dons.
A last-minute goal by Paul Mullin saw League Two Accrington Stanley topple Walsall 2-1, who had to play for 55 minutes with 10 men.
The League One side went ahead through Alex Nicholl's early right-footed shot but were then reduced to 10 men 10 minutes before half-time when Rhys Weston got his second yellow card. Robert Grant (53) levelled before Mullins' late intervention.
A goal two minutes from time gave Southend a 2-1 win at Cheltenham.
Elvis Hammond gave the hosts the lead on the stroke of half time before Lee Barnard equalised with 13 minutes left and the same player headed the Shrimpers to a late victory.
A last-minute header from Scott Dobie earned Carlisle a win over Oldham, Darryl Duffy scored twice - and missed a penalty - as Bristol Rovers beat Aldershot 2-1 and Huddersfield beat Stockport 3-1 thanks to a Jordan Rhodes double and a Theo Robinson strike.
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