Wales have lost defender Danny Gabbidon from their two World Cup qualifiers against Finland and Liechtenstein over the next week.
The West Ham player has pulled out with a calf injury that has stopped him training for the past fortnight.
It is a bitter blow for Gabbidon, who has been easing himself back to top-level action this season after being dogged by injuries for two years with persistent injuries.
Gabbidon made his Wales comeback against Montenegro in August, and also figured against Russia last month, but he is now out of the Finland clash in Helsinki on Saturday and next Wednesday's final qualifier in Liechtenstein.
Wales will also make a decision on Wednesday over the fitness of Cardiff's midfielder Joe Ledley.
Ledley is suffering from a pelvic injury and had a scan on Tuesday to assess the problem. Ledley will now see a specialist, with the likelihood that he will now also miss the Group Four qualifiers.
Skipper Craig Bellamy reported to the squad's team hotel this evening and is fit to travel, despite worries that he had picked up a knee problem while scoring for Manchester City in their 1-1 draw at Aston Villa on Monday.
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