Leading goalscorer Rob Hulse will miss Derby's trip to Holland to receive treatment on a groin injury.
The Rams are set to play Eredivisie side ADO Den Haag on Thursday night at the Dutch club's Forepark Stadium.
Hulse, who took his goal tally for the season to five with a double in the 2-1 home win over Coventry at the weekend, will not travel in a bid to be fit to face Swansea when the Championship programme resumes after the international break on November 20.
Full-back Paul Connolly will also remain behind after having an injection for a foot injury.
"Rob will need four or five days rest to allow the groin to settle after the injection and then he will be able to train again," Manager Nigel Clough told the Derby Telegraph. "Paul had an injection in his foot after the game on Friday night, so it will be a week or so to let it settle down and he should be available to train next week."
Clough will use the game against Den Haag to give a run-out to players coming back from injury, he added: "It means the likes of Miles Addison, Dean Leacock, Lee Croft and Bryan Hughes will get some much-needed match action."
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