City boss Nigel Pearson will hope the postponement of last weekend`s clash with Cardiff has given the duo the time they need to recover.
Berner was a doubt for the trip to south Wales after a calf injury forced the Swiss full-back off during the victory over Sheffield Wednesday, while centre-half Brown was nursing a knock.
However, that game being called off means that on-loan striker Martyn Waghorn still has two games of a three-match suspension to serve. He will miss the Blades` Boxing Day visit to the Walkers Stadium and the trip to Doncaster two days later.
Club captain Stephen Clemence continues to progress in his recovery from a persistent heel injury and the midfielder could end a 21-month absence by making a long-awaited comeback in January.
United duo Lee Williamson and Darius Henderson have both been ruled out through injury until the beginning of February ahead of the trip to the Midlands.
Summer signing Williamson is struggling with a hamstring problem and striker Henderson has pulled a gluteal muscle.
Manager Kevin Blackwell said: "If either player is back in contention before the end of January it would be an unexpected bonus."
But Ched Evans (ear infection) and Andy Taylor (virus) could return and Blackwell is hoping to extend Fulham defender Toni Kallio's loan spell in time for the Finland international to feature.
The Blades, two points behind Leicester, are hoping to leapfrog the Foxes into the play-off places by extending their unbeaten league run to seven matches.
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