Blackpool boss Ian Holloway looks set to be handed a triple boost ahead of the trip to Derby.
Midfielder Charlie Adam has been struggling with a calf strain but has made steady progress and is on course to be passed fit to face the Rams.
Striker Ben Burgess has been nursing a knee injury but he could also be available to boost Holloway's attacking options.
Defender Marcel Seip has recovered from a hamstring problem and may also come into contention for the Pride Park clash.
Holloway said: "If Charlie, Ben and Marcel are all available for Saturday - and the signs are they might be - then it would be a dream come true."
Midfielder David Vaughan serves a one-match ban but Holloway has recalled in-form striker Daniel Nardiello from his loan spell at Bury.
Sheffield Wednesday will be without suspended striker Luke Varney.
Varney, who sits out a one-game ban after receiving his fifth booking of the season in the Boxing Day draw with Newcastle, could have played his last game for the Owls as he was due to return to parent club Derby after the Seasiders clash.
Leon Clarke replaced Varney midway through the second half against Newcastle and is expected to return to the starting line-up alongside Marcus Tudgay.
Caretaker manager Sean McAuley switched to a 4-3-3 formation on Boxing Day and could be tempted to stick with it after one of the Owls' best displays of the season.
Frank Simek and Tom Soares, on loan from Stoke, will be hoping to retain their places in the starting line-up after replacing Lewis Buxton and Sean McAlister respectively, while Etienne Esajas and Jermaine Johnson are vying for one of the three places up front.
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