Tony Bellew has called for Luis Ortiz to be banned for life after the Cuban failed a drug test for the second time in his career.
Ortiz, who has been set to face Deontay Wilder for the WBC heavyweight title on November 4, has previously been suspended and stripped of the WBA interim heavyweight title in 2014 after failing a test.
The fight against Wilder is now to be cancelled, according to ESPN, with the 38-year-old likely to get a lengthy suspension if the following investigation doesn't clear him.
November 4 had been highly anticipated, with both Wilder and Ortiz undefeated and facing their toughest opponent yet.
The status of the fight wasn't lost on Wilder, who had issued a plea to Ortiz at a press conference.
"Stay clean, because we'll be checking. Stay clean. Don't f--- this up for me, nor you, because I'm gonna prove to the world that I am the best," Wilder had said.
Instead, Ortiz appears to have messed it up for both of them, his "A" sample testing positive for banned substances and potential masking-agents chlorothiazide and hydrochlorothiazide.
Wilder's promoter Lou Dibella spoke on the failure, saying: "I can verify the information Mauricio put out. I'm flabbergasted and particularly crestfallen for my fighter.
"Deontay Wilder is a great champion and a clean champion and probably has been victimized more than any other fighter in the history of the sport."
Meanwhile, Tony Bellew took to Twitter immediately after the revelation, calling for the Cuban to be banned for life after failing for the second time.
The result will shake up the division for sure, with Wilder needing a new challenger.
WBO heavyweight champion Joseph Parker, too, is on the lookout for a challenger after defeating Hughie Fury.
While potential unification fights with Anthony Joshua are being pursued by all.